When depression hasn’t improved despite multiple medications, Spravato® (esketamine) may offer a clinically proven option. Treatment is administered in-clinic with careful monitoring and combined with an oral antidepressant as part of a structured care plan.
Spravato® is FDA-approved for adults with treatment-resistant depression and used under strict clinical guidelines.
Spravato® is a nasal spray taken in-clinic—no surgery, no needles, and no anesthesia required.
Many major insurance plans cover Spravato®. Our team helps verify benefits and manages the approval process for you.
Treatment sessions include a short observation period. Most patients return home the same day, though you’ll need a ride after your visit.
Spravato® (esketamine) is an FDA-approved treatment for adults with treatment-resistant depression. It works differently from traditional antidepressants by targeting the brain’s glutamate system, which plays a role in mood regulation and neural communication.
For individuals living with Treatment-Resistant Depression who haven’t found relief from multiple antidepressants, Spravato® may offer a new option. By acting on different brain pathways, it may help reduce depressive symptoms when standard treatments haven’t been effective.
Spravato® treatment is personalized and guided by a comprehensive psychiatric evaluation. It is administered as a nasal spray in a certified clinical setting and must be used alongside an oral antidepressant, following FDA-approved protocols.
During each session, patients self-administer Spravato® under medical supervision and remain in the clinic for a monitored observation period. This allows the care team to ensure safety, comfort, and proper recovery after treatment.
Most patients return home the same day following observation. Treatment schedules and dosing are adjusted over time based on response and ongoing evaluation by the psychiatric provider.
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I had been struggling with depression since childhood, but Bright Horizons Psychiatry exceeded my expectations, guiding me from darkness to hope. Through compassionate care and effective treatments like Esketamine and TMS, I feel lighter, more positive, and truly on the path to recovery.
Bright Horizons exceeded my expectations, guiding me from darkness to hope. With caring staff and effective treatment, I feel lighter, more positive, and on the path to recovery from depression.
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Spravato® is an FDA-approved nasal spray used for adults with treatment-resistant depression. Unlike traditional antidepressants that mainly affect serotonin, Spravato® works on the brain’s glutamate system, which plays a role in mood and brain connectivity.
Because of this different mechanism, Spravato® may help people who haven’t improved after trying multiple antidepressant medications.
Spravato® may be an option for adults who have tried two or more antidepressants without adequate relief. Before starting treatment, you’ll meet with a psychiatric provider for a full evaluation to determine whether Spravato® is appropriate and safe for you.
Not everyone qualifies, and eligibility depends on medical history, current medications, and overall mental health needs.
During a session, you’ll self-administer Spravato® nasal spray in the clinic under medical supervision. After dosing, you’ll remain in a comfortable setting for a required observation period so the care team can monitor your response and ensure your safety.
You won’t be able to drive yourself home, so arranging transportation is required.
Spravato® follows a structured treatment schedule. Most patients start with twice-weekly sessions, then gradually move to weekly or less frequent maintenance visits, depending on response.
Your provider will regularly assess progress and adjust the schedule as needed to support long-term symptom management.
Yes, many major insurance plans cover Spravato® for eligible patients. Coverage varies by plan, and prior authorization is usually required.
Our team helps verify benefits, submit paperwork, and guide you through the approval process so there are no surprises.
Some patients experience temporary side effects such as dizziness, nausea, dissociation, fatigue, or changes in perception. These effects usually happen during or shortly after treatment and typically resolve the same day.
You’ll be monitored throughout your visit, and your provider will review potential risks and side effects with you before starting treatment.
If depression hasn’t improved despite trying multiple medications, Spravato® may be an option worth exploring. Our experienced care team is here to answer your questions, review your history, and help you understand whether this FDA-approved treatment is right for you.
Schedule a free consultation today to learn whether Esketamine (Spravato®) is right for you and get answers from a qualified care team.